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Clostridium difficile Strains Isolated from Patients withC. difficile -associated Disease in Korea - Seung-Hak Cho, Jung-Whan Chon, Kun-Ho Seo, Young Kwon Kim, Jung-Beom Kim, Young-Seok Bak, Woon-Won Jung, Cheorl-Ho Kim, Jong Tae Choi
- Osong Public Health Res Perspect. 2017;8(5):325-331. Published online October 31, 2017
- DOI: https://doi.org/10.24171/j.phrp.2017.8.5.06
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Abstract
PDF Objectives Studies on
Clostridium difficile are rare in Korea. We investigated the epidemiological characteristics ofC. difficile isolates from patients withC. difficile -associated disease (CDAD) in Korea.Methods Multiplex polymerase chain reaction was performed to detect the presence of
tcdA andtcdB toxin genes. Antimicrobial susceptibility test was carried out by the disk-dilution method.C. difficile strains were subtyped by automated repetitive-element palindromic PCR (rep-PCR).Results Among patients with CDAD, 73 (25.8%), 32 (11.3%), 32 (11.3%), and 26 (9.2%) suffered from pneumonia, cancer or neoplasm, diabetes, and colitis, respectively. Of all stool samples, 43 samples (15.2%) were positive for
C. difficile strains. We observed two expression patterns of toxin genes:tcdA +/tcdB + (86% isolates) andtcdA −/tcdB + (14% isolates), with all isolates expressingtcdB . Furthermore, some isolates were resistant to clindamycin (65%), ampicillin (56%), and cefazolin (40%), but all were susceptible to vancomycin and metronidazole. The tested samples were classified into diverse clusters using automated rep-PCR.Conclusion Our findings revealed the characteristics and antibiotic resistance of
C. difficile isolates from patients in Korea. The epidemiological data may provide valuable insight into development of treatment strategies forC. difficile infections in Korea.-
Citations
Citations to this article as recorded by
- Metronidazole therapy as initial treatment of Clostridium difficile infection in patients with chronic kidney disease in Korea
Jaeuk Shin, Yu Mi Wi, Yu-Ji Lee
Epidemiology and Infection.2019;[Epub] CrossRef
- Metronidazole therapy as initial treatment of Clostridium difficile infection in patients with chronic kidney disease in Korea
- Antibiotic Resistance Patterns and Serotypes of
Salmonella spp. Isolated at Jeollanam-do in Korea - Ki-Bok Yoon, Byung-Joon Song, Mi-Yeong Shin, Hyun-Cheol Lim, Yeon-Hee Yoon, Doo-Young Jeon, Hoon Ha, Soo-In Yang, Jung-Beom Kim
- Osong Public Health Res Perspect. 2017;8(3):211-219. Published online June 30, 2017
- DOI: https://doi.org/10.24171/j.phrp.2017.8.3.08
- 5,062 View
- 45 Download
- 16 Crossref
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Abstract
PDF
Objectives Few long-term studies have been conducted on the serotype and antibiotic resistance patterns of
Salmonella speices (spp.) The aim of this study was to determine the serotypes and antibiotic resistance patterns ofSalmonella spp. isolated at Jeollanam-do in Korea from 2004 to 2014.Methods A total of 276
Salmonella samples were evaluated. Serotyping was carried out according to the Kauffmann–White scheme. Antibiotic susceptibility was determined using the Vitek II system with an AST-N169 card.Results A total of 22 different serotypes were identified, and the major serotypes were
Salmonella Enteritidis (116 strains, 42.0%) andSalmonella Typhimurium (60 strains, 21.7%). The highest resistance was observed in response to nalidixic acid (43.4%), followed by ampicillin (40.5%) and tetracycline (31.6%). Resistance to nalidixic acid was detected in 81.0% ofS . Enteritidis. Multidrug resistance was detected in 43.3% ofSalmonella spp.S . Enteritidis andS . Typhimurium presented the highest resistance (98.3%) and multidrug resistance rate (73.3%), respectively. The most highly observed antibiotic resistance pattern amongSalmonella spp. in this study was ampicillin-chloramphenicol (14 strains, 5.7%),Conclusion Overall,
S . Enteritidis andS . Typhimurium showed higher antibiotic resistance than the otherSalmonella serotypes tested in this study. Our study will provide useful information for investigating the sources ofSalmonella infections, as well as selecting effective antibiotics for treatment.-
Citations
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Korean Journal of Veterinary Service.2023; 46(3): 211. CrossRef - Trends in ESBLs and PABLs among enteric Salmonella isolates from children in Gwangju, Korea: 2014–2018
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